3-Methylbutanal → HCID 76587709, compound

HRID 888666Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:41])[CH:4]([C:9]1[CH:10]=[C:11]([C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=2)[CH:12]=[C:13]([NH:15][CH2:16][C:17]2[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([C:27]([F:30])([F:29])[F:28])[CH:18]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[CH:42](=O)[CH2:43][CH:44]([CH3:46])[CH3:45]>>[CH3:1][O:2][C:3](=[O:41])[CH:4]([C:9]1[CH:10]=[C:11]([C:31]2[CH:32]=[CH:33][C:34]([C:37]([F:38])([F:39])[F:40])=[CH:35][CH:36]=2)[CH:12]=[C:13]([N:15]([CH2:16][C:17]2[CH:18]=[C:19]([C:27]([F:28])([F:29])[F:30])[CH:20]=[C:21]([C:23]([F:25])([F:26])[F:24])[CH:22]=2)[CH2:42][CH2:43][CH:44]([CH3:46])[CH3:45])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

Reactant 2

HCID 115523-Methylbutanal

HCID 76587707HCID 76587707, compound

Product 1

HCID 76587709HCID 76587709, compound

Procedure

Following the procedure of Example 39, step (a), reaction of 2-[5-(3,5-Bis-trifluoromethyl-benzylamino)-4′-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester, compound 46a with isovaleraldehyde gave the title compound; Calcd. MW 661.66. Found MH+ 662.4.

Sources & evidence

ORD record: ord-ff7cedc552b84d91aac4bb6c134edef1
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08247610B2

Reaction notes

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