3,4,5-Trifluorobenzaldehyde → HCID 57666666, compound

HRID 888669Notes

Reaction equation

HRID 888669 reaction equation
ClC1C=C(C=CC=1CF)C=O.FC1C=C(C=C(F)C=1F)C=O.[CH2:23]([O:25][C:26](=[O:64])[CH:27]([C:32]1[CH:33]=[C:34]([C:54]2[CH:59]=[CH:58][C:57]([C:60]([F:63])([F:62])[F:61])=[CH:56][CH:55]=2)[CH:35]=[C:36]([CH2:38][N:39]([CH2:45][C:46]2[CH:51]=[CH:50][C:49]([Cl:52])=[C:48]([F:53])[CH:47]=2)[CH2:40][CH2:41][CH:42]([CH3:44])[CH3:43])[CH:37]=1)CC(C)C)[CH3:24]>>[CH2:23]([O:25][C:26](=[O:64])[CH2:27][C:32]1[CH:33]=[C:34]([C:54]2[CH:55]=[CH:56][C:57]([C:60]([F:62])([F:63])[F:61])=[CH:58][CH:59]=2)[CH:35]=[C:36]([CH2:38][N:39]([CH2:45][C:46]2[CH:51]=[CH:50][C:49]([Cl:52])=[C:48]([F:53])[CH:47]=2)[CH2:40][CH2:41][CH:42]([CH3:44])[CH3:43])[CH:37]=1)[CH3:24]

Participants

4

Reactant 3

HCID 27769543,4,5-TrifluorobenzaldehydeHCID 69082381HCID 69082381, compoundHCID 86629864HCID 86629864, compound

Product 1

HCID 57666666HCID 57666666, compound

Procedure

Using the procedure described for Example 54, except substituting compound 57c for compound 54c and 3-chloro-4-fluoromethylbenzaldehyde for 3,4,5-trifluorobenzaldehyde, compound 57c was converted to 2-(5-{[(4-chloro-3-fluoro-benzyl)-(3-methyl-butyl)-amino]-methyl}-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid ethyl ester as a milky glass.

Sources & evidence

ORD record
ord-77856ada781f4c40a6b13bfb8e082703
Source dataset
uspto-grants-2012_08
Patent number
US08247610B2

Reaction notes

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