Morpholine → HCID 86639718, compound

Participants

Reaction Steps

To a solution of 4C (168 mg, 0.158 mmol) in dry CH3OH (5 mL) at rt was added morpholine (27.6 μl, 0.48 mmol) followed by Pd(PPh3)4 (18.3 mg, 0.016 mmol). After stirring for 2 h the solvent was evaporated, the product rinsed with CH2Cl2 and washed with 1 M HCl (10 mL), sat NaHCO3 (10 mL) and sat. NaCl (10 mL) solutions. The organic layer was then dried with MgSO4 and filtered, the solvent was removed in vacuo and the crude product was washed with hexane (3×20 mL) and purified by flash chromatography (1-20% CH3OH/CHCl3) to give 5C (101 mg, 0.1 mmol, 63%).

Provenance & Evidence