Acetic Acid → HCID 59223125, compound

Participants

Reaction Steps

To a solution of 4D (170 mg, 0.159 mmol), Pd(PPh3)4 (9 mg, 0.008 mmol) in dry methanol (6 mL) under argon was added morpholine (28 μL, 0.32 mmol) which was allowed to stir for 3 h. The reaction mixture was concentrated in vacuo, CH2Cl2 (20 mL) was then added before washing with 1M HCl (15 mL), sat. sodium hydrogen carbonate (15 mL), sat. brine (15 mL), dried over MgSO4 and concentrated in vacuo. Purification was then carried out by column chromatography on silica gel (5-8% MeOH/CH2Cl2 then +0.2% AcOH) to give 5D (130 mg, 0.13 mmol, 61%).

Provenance & Evidence