4-Fluorobenzoic Acid → 4-Fluorobenzoyl chloride

Participants

Reaction Conditions

Reaction Steps

Thionyl chloride (3.8 g, 32.1 mmol) was slowly added to a solution of 4-fluorobenzoic acid 1a (3.0 g, 21.4 mmol) and N,N-dimethylformamide (5 drops) in 15 mL of chlorobenzene under a stream of nitrogen gas. The mixture was stirred at 60° C. for 2 hr. The solvent was removed under reduced pressure to afford 4-fluorobenzoyl chloride 1b. Yield: 3.0 g (88%).

Provenance & Evidence