反应详情

温度

20 °C

0.053 g (1.334 mmol) of 2 molar aqueous sodium hydroxide solution was added to 0.114 g (0.334 mmol) of methyl [5-(3-chlorophenyl)-3-methyl-1-pyridin-3-yl-1H-pyrazol-4-yl]acetate (see A1), and the mixture was stirred at 20° C. for 1 h. The methanol formed during the reaction was removed under reduced pressure, and the residue was poured onto a mixture of 10 ml of water and 15 ml of dichloromethane. The aqueous phase was extracted with 15 ml of dichloromethane, acidified with concentrated hydrochloric acid (pH=3) and extracted three times with in each case 15 ml of dichloromethane. Drying of the combined organic phases and removal of the solvent under reduced pressure give 0.050 g (43% of theory) of a light-beige solid of melting point 163° C.

1. customwas removed under reduced pressure
2. additionthe residue was poured onto a mixture of 10 ml of water and 15 ml of dichloromethane
3. extractionThe aqueous phase was extracted with 15 ml of dichloromethane
4. extractionextracted three times with in each case 15 ml of dichloromethane
5. customDrying of the combined organic phases and removal of the solvent under reduced pressure
6. customgive 0.050 g (43% of theory) of a light-beige solid of melting point 163° C.