HCID 67303368, compound → HCID 67303639, compound

Participants

Reaction Steps

A solution of benzyl 2-(adamantan-2-yl)-3-oxo-1,2-diazetidine-1-carboxylate (100 mg, 0.29 mmol) in tetrahydrofuran (5 mL) was added with 10% palladium carbon (catalyst amount), and under a hydrogen atmosphere, the resultant was stirred at room temperature for 10 hours. The reaction solution was filtered using celite, concentrated in vacuo, and the obtained residue was purified using silica gel chromatography (hexane:ethyl acetate=1:1), and 2-(adamantan-2-yl)-1,2-diazetidin-3-one (34.0 mg, 56.8%) was obtained as a colorless oil.

Provenance & Evidence