1-(Bromomethyl)-2-(trifluoromethyl)benzene → HCID 46194925, compound

HRID 888769Notes

Reaction equation

HRID 888769 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[C:14](=[O:15])[CH:13]([CH2:16][CH2:17][CH2:18][CH3:19])[NH:12]1)[CH2:8]2.[F:20][C:21]([F:31])([F:30])[C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24]Br>>[CH2:16]([CH:13]1[N:12]([CH2:24][C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[C:21]([F:20])([F:30])[F:31])[N:11]([CH:2]2[CH:3]3[CH2:4][CH:5]4[CH2:6][CH:7]([CH2:8][CH:1]2[CH2:10]4)[CH2:9]3)[C:14]1=[O:15])[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 67302883HCID 67302883, compound

Product 1

HCID 46194925HCID 46194925, compound

Procedure

2-(Adamantan-2-yl)-4-butyl-1,2-diazetidin-3-one and 2-(trifluoromethyl)benzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and the title compound was obtained as a white crystalline powder.

Sources & evidence

ORD record
ord-4a78a35e1f0f41a19bc00068716a7752
Source dataset
uspto-grants-2012_08
Patent number
US08252781B2

Reaction notes

Loading…