3,5-Difluorobenzyl bromide → 1-(3,5-Difluorobenzyl)-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one

HRID 888775Notes

Reaction equation

HRID 888775 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[NH:12]1)[CH2:8]2.[F:18][C:19]1[CH:20]=[C:21]([CH:24]=[C:25]([F:27])[CH:26]=1)[CH2:22]Br>>[F:18][C:19]1[CH:20]=[C:21]([CH:24]=[C:25]([F:27])[CH:26]=1)[CH2:22][N:12]1[C:13]([CH3:17])([CH3:16])[C:14](=[O:15])[N:11]1[CH:2]1[CH:3]2[CH2:4][CH:5]3[CH2:6][CH:7]([CH2:8][CH:1]1[CH2:10]3)[CH2:9]2

Participants

3

Reactant 2

HCID 5188963,5-Difluorobenzyl bromideHCID 673028822-(Adamantan-2-yl)-4,4-dimethyl-1,2-diazetidin-3-one

Product 1

HCID 461950621-(3,5-Difluorobenzyl)-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one

Procedure

2-(Adamantan-2-yl)-4,4-dimethyl-1,2-diazetidin-3-one and 3,5-difluorobenzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and the title compound was obtained as a white crystalline powder.

Sources & evidence

ORD record
ord-fb2e167693494553ab6180464a1689d4
Source dataset
uspto-grants-2012_08
Patent number
US08252781B2

Reaction notes

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