1-(Bromomethyl)-2-phenylbenzene → 1-(Biphenyl-2-ylmethyl)-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one

HRID 888806Notes

Reaction equation

HRID 888806 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[NH:12]1)[CH2:8]2.[C:18]1([C:24]2[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=2[CH2:26]Br)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:24]1([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][N:12]1[C:13]([CH3:17])([CH3:16])[C:14](=[O:15])[N:11]1[CH:2]1[CH:3]2[CH2:4][CH:5]3[CH2:6][CH:7]([CH2:8][CH:1]1[CH2:10]3)[CH2:9]2

Participants

3

Reactant 2

HCID 2633651-(Bromomethyl)-2-phenylbenzeneHCID 673028822-(Adamantan-2-yl)-4,4-dimethyl-1,2-diazetidin-3-one

Product 1

HCID 461955051-(Biphenyl-2-ylmethyl)-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one

Procedure

2-(Adamantan-2-yl)-4,4-dimethyl-1,2-diazetidin-3-one and 2-phenylbenzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and the title compound was obtained as a colorless oil.

Sources & evidence

ORD record
ord-46bf6bbf2ada4a3eb5548151bb9af5b6
Source dataset
uspto-grants-2012_08
Patent number
US08252781B2

Reaction notes

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