4-(Bromomethyl)benzo[d][1,3]dioxole → 1-(1,3-Benzodioxol-4-ylmethyl)-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one

HRID 888818Notes

Reaction equation

HRID 888818 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[N:11]1[C:14](=[O:15])[C:13]([CH3:17])([CH3:16])[NH:12]1)[CH2:8]2.[CH2:18]1[O:28][C:27]2[C:20](=[C:21]([CH:24]=[CH:25][CH:26]=2)[CH2:22]Br)[O:19]1>>[O:28]1[C:27]2[CH:26]=[CH:25][CH:24]=[C:21]([CH2:22][N:12]3[C:13]([CH3:17])([CH3:16])[C:14](=[O:15])[N:11]3[CH:2]3[CH:3]4[CH2:4][CH:5]5[CH2:6][CH:7]([CH2:8][CH:1]3[CH2:10]5)[CH2:9]4)[C:20]=2[O:19][CH2:18]1

Participants

3

Reactant 2

HCID 225059674-(Bromomethyl)benzo[d][1,3]dioxoleHCID 673028822-(Adamantan-2-yl)-4,4-dimethyl-1,2-diazetidin-3-one

Product 1

HCID 461955111-(1,3-Benzodioxol-4-ylmethyl)-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one

Procedure

2-(Adamantan-2-yl)-4,4-dimethyl-1,2-diazetidin-3-one and 2,3-(methylenedioxy)benzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and the title compound was obtained as a white crystalline powder.

Sources & evidence

ORD record
ord-8a99b834f61346a3945d9e287f698895
Source dataset
uspto-grants-2012_08
Patent number
US08252781B2

Reaction notes

Loading…