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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 888832Generated: November 1, 2026

1-(Bromomethyl)-2-chloro-4-fluorobenzene → 1-(2-Chloro-4-fluorobenzyl)-2-cyclooctyl-4,4-dimethyl-1,2-diazetidin-3-one

https://huagongshe.com/reaction/888832

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-2-chloro-4-fluorobenzeneHCID 2725062—
Reactant2-Cyclooctyl-4,4-dimethyl-1,2-diazetidin-3-oneHCID 67302983—
Product1-(2-Chloro-4-fluorobenzyl)-2-cyclooctyl-4,4-dimethyl-1,2-diazetidin-3-oneHCID 59361398—

Reaction Steps

2-Cyclooctyl-4,4-dimethyl-1,2-diazetidin-3-one and 2-chloro-4-fluorobenzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and the title compound was obtained as a colorless crystalline powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08252781B2
Source datasetuspto-grants-2012_08
ORD IDord-3756b5694dea4eef87ed49b4a2f5de74
Source noteuspto-grants-2012_08