4-Fluorobenzyl bromide → HCID 67303435, compound

HRID 888848Notes

Reaction equation

HRID 888848 reaction equation
[CH3:1][C:2]1([CH3:21])[C:5](=[O:6])[N:4]([CH:7]2[CH:14]3[CH2:15][C:10]4([C:17]([O:19][CH3:20])=[O:18])[CH2:11][CH:12]([CH2:16][CH:8]2[CH2:9]4)[CH2:13]3)[NH:3]1.[F:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27]Br)=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][N:3]2[C:2]([CH3:21])([CH3:1])[C:5](=[O:6])[N:4]2[CH:7]2[CH:8]3[CH2:9][C:10]4([C:17]([O:19][CH3:20])=[O:18])[CH2:11][CH:12]([CH2:13][CH:14]2[CH2:15]4)[CH2:16]3)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 67302904HCID 67302904, compound

Product 1

HCID 67303435HCID 67303435, compound

Procedure

Methyl 4-(3,3-dimethyl-4-oxo-1,2-diazetidin-1-yl)adamantane-1-carboxylate and 4-fluorobenzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and methyl 4-[2-(4-fluorobenzyl)-3,3-dimethyl-4-oxo-1,2-diazetidin-1-yl]adamantane-1-carboxylate was obtained as a colorless oil.

Sources & evidence

ORD record
ord-ddc45a84cb2b482fa0f5a092967232a4
Source dataset
uspto-grants-2012_08
Patent number
US08252781B2

Reaction notes

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