alpha-Bromo-o-chlorotoluene → HCID 67302992, compound

HRID 888854Notes

Reaction equation

HRID 888854 reaction equation
[CH3:1][C:2]1([CH3:21])[C:5](=[O:6])[N:4]([CH:7]2[CH:14]3[CH2:15][C:10]4([C:17]([O:19][CH3:20])=[O:18])[CH2:11][CH:12]([CH2:16][CH:8]2[CH2:9]4)[CH2:13]3)[NH:3]1.[Cl:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25]Br>>[Cl:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25][N:3]1[C:2]([CH3:21])([CH3:1])[C:5](=[O:6])[N:4]1[CH:7]1[CH:8]2[CH2:9][C:10]3([C:17]([O:19][CH3:20])=[O:18])[CH2:11][CH:12]([CH2:13][CH:14]1[CH2:15]3)[CH2:16]2

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 67302904HCID 67302904, compound

Product 1

HCID 67302992HCID 67302992, compound

Procedure

Methyl 4-(3,3-dimethyl-4-oxo-1,2-diazetidin-1-yl)adamantane-1-carboxylate prepared in Process 5 of Example 90, and 2-chlorobenzyl bromide were used for a similar reaction and treatment as Process 6 of Example 1, and methyl 4-[2-(2-chlorobenzyl)-3,3-dimethyl-4-oxo-1,2-diazetidin-1-yl]adamantane-1-carboxylate was obtained as a pale yellow oil.

Workup

  1. customwere used for a similar reaction and treatment as Process 6 of Example 1

Sources & evidence

ORD record
ord-f8184188fc414acabac626347d453c7d
Source dataset
uspto-grants-2012_08
Patent number
US08252781B2

Reaction notes

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