HCID 59361467, compound → HCID 59361525, compound

Participants

Reaction Steps

A solution of 4,4-dimethyl-1-[(2-nitrophenyl)carbonyl]-2-(adamantan-2-yl)-1,2-diazetidin-3-one (16.7 mg, 0.0436 mmol) prepared in Example 124 in ethanol-tetrahydrofuran was added with 10% palladium carbon (catalyst amount), and under a hydrogen atmosphere, the resultant was stirred at room temperature for 1 hour. The reaction solution was filtered using celite and concentrated in vacuo. The obtained residue was purified using Preparative Thin-Layer chromatography (hexane:ethyl acetate=2:1), and the title compound (14.8 mg, 96.1%) was obtained as a white crystalline solid.

Provenance & Evidence