Hydrochloric Acid → HCID 59361405, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-[4-(methoxymethoxy)phenyl]-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one (62.5 mg, 0.169 mmol) prepared in Example 214 in methanol was added with concentrated hydrochloric acid (0.3 mL) under ice-cold conditions, and the resultant was stirred at 50° C. for 30 minutes. The reaction solution was added under ice-cold conditions with a saturated aqueous solution of ammonium chloride, extracted with chloroform, and concentrated in vacuo. The obtained residue was purified using Preparatory Thin-Layer chromatography (chloroform:methanol=10:1), and the title compound (38.0 mg, 68.8%) was obtained as a white crystalline solid.

Provenance & Evidence