HCID 59361395, compound → HCID 67302960, compound

Participants

Reaction Steps

A solution of 1-[(benzyloxy)acetyl]-4,4-dimethyl-2-(adamantan-2-yl)-1,2-diazetidin-3-one (151 mg, 0.400 mmol) prepared in Example 263 in ethanol (3 mL) was added with 10% palladium carbon (catalyst amount), and under a hydrogen atmosphere the resultant was stirred at room temperature for 20 hours. The reaction solution was filtered using celite, concentrated in vacuo, the obtained residue was purified using silica gel chromatography (hexane:ethyl acetate=2:1), and 4,4-dimethyl-1-(hydroxyacetyl)-2-(adamantan-2-yl)-1,2-diazetidin-3-one (52.0 mg, 44.5%) was obtained as a white crystalline powder.

Provenance & Evidence