Ammonium Chloride → HCID 67302996, compound

Participants

Reaction Steps

Under an argon atmosphere, a mixed solution of ethyl [4,4-dimethyl-3-oxo-2-(adamantan-2-yl)-1,2-diazetidin-1-yl]acetate (150 mg, 0.470 mmol) in tetrahydrofuran-methanol-water (10:1:1, 4 mL) was added with lithium borohydride (80.8 mg, 3.76 mmol) at room temperature, and the resultant was stirred at the same temperature for 1 hour. The reaction solution was added with a saturated aqueous solution of ammonium chloride, and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, concentrated in vacuo, the obtained residue was purified using silica gel chromatography (hexane:ethyl acetate=2:1), and 4,4-dimethyl-1-(2-hydroxyethyl)-2-(adamantan-2-yl)-1,2-diazetidin-3-one (163 mg, 78.7%) was obtained as a colorless oil.

Provenance & Evidence