Morpholine → 2-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Morpholine	HCID 8083	—
Reactant	2,4-Dichlorothieno[3,2-d]pyrimidine	HCID 12712832	—
Solvent	Methanol	HCID 887	—
Product	2-Chloro-4-(morpholin-4-yl)thieno(3,2-d)pyrimidine	HCID 20284971	100%

Reaction Steps

A mixture of 2,4-dichloro-thieno[3,2-d]pyrimidine (8.68 g, 42.34 mmol), morpholine (8.11 mL, 2.2 equivalents) and methanol (150 mL) was stirred at room temperature for 1 hour. The reaction mixture was then filtered, washed with water to yield the title compound as a white solid (11.04 g, 100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08252792B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-16b03d146fed4e318382219025253f8b
Source note	uspto-grants-2012_08