HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 59151328, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | 4-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 46180726 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59151328 | HCID 59151328 | 77.3% |
Reaction Steps
To a solution of 6-bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (150 mg, 0.43 mmol) in DMF (4 mL) were added (cis)-2,6-dimethyl-piperazine (74 mg, 0.648 mmol) and potassium carbonate (117 mg, 0.847 mmol). The resulting mixture was stirred at RT for 17 h, then concentrated in vacuo. The resulting residue was triturated with water to give the title compound as an off-white solid (127 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252792B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-c1f8dde96ab848d6afc455d04d0ed961 |
| Source note | uspto-grants-2012_08 |