HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-tert-Butoxycarbonyl-1-[(3-chloro-1-propyl)sulfonyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloropropanesulphonyl chloride | HCID 15410 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-tert-Butoxycarbonyl-1-[(3-chloro-1-propyl)sulfonyl]piperazine | HCID 22709890 | — |
Reaction Steps
To a solution of 1-BOC-piperazine (3.26 g) and triethylamine (2.68 mL) in dry chloroform (25 mL) was added 3-chloropropanesulfonyl chloride (2.62 g) at 0° C. After 2 h wash with water, dry (Na2SO4), filter and concentrate to give crude material. Product was isolated by flash chromatography (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252792B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-fee62c3a27c8409cbe739d616d8c5ef7 |
| Source note | uspto-grants-2012_08 |