3-(Dimethylamino)pyrrolidine → HCID 59151336, compound

HRID 888957Notes

Reaction equation

HRID 888957 reaction equation
[CH3:1][C@H:2]1[NH:7][C@@H:6](C)[CH2:5][N:4]([CH2:9][C:10]2[S:18][C:17]3[C:16]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[N:15][C:14]([C:25]4[CH:33]=[C:32]([F:34])[CH:31]=[C:30]5[C:26]=4[CH:27]=[CH:28][NH:29]5)=[N:13][C:12]=3[CH:11]=2)[CH2:3]1.[CH3:35]N(C)C1CCNC1>>[F:34][C:32]1[CH:31]=[C:30]2[C:26]([CH:27]=[CH:28][NH:29]2)=[C:25]([C:14]2[N:15]=[C:16]([N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[C:17]3[S:18][C:10]([CH2:9][N:4]4[CH2:5][CH2:1][CH:2]([N:7]([CH3:6])[CH3:35])[CH2:3]4)=[CH:11][C:12]=3[N:13]=2)[CH:33]=1

Participants

3

Reactant 2

HCID 27585193-(Dimethylamino)pyrrolidineHCID 24936355HCID 24936355, compound

Product 1

HCID 59151336HCID 59151336, compound

Procedure

Prepared according to the method used in the preparation of 6-(cis-3,5-dimethyl-piperazin-1-ylmethyl)-2-(6-fluoro-1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using dimethyl-pyrrolidin-3-yl-amine in place of 2,6-dimethyl-piperazine. The title compound was obtained as a white solid (21.8 mg, 36%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-951439d125c74f48988f2fdf73f289fe
Source dataset
uspto-grants-2012_08
Patent number
US08252792B2

Reaction notes

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