4-(N-Boc-amino)piperidine → HCID 59151279, compound

HRID 888959Notes

Reaction equation

HRID 888959 reaction equation
[CH3:1][C@H:2]1N[C@@H:6](C)[CH2:5][N:4]([CH2:9][C:10]2[S:18][C:17]3[C:16]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[N:15][C:14]([C:25]4[CH:33]=[C:32]([F:34])[CH:31]=[C:30]5[C:26]=4[CH:27]=[CH:28][NH:29]5)=[N:13][C:12]=3[CH:11]=2)[CH2:3]1.C(OC(=O)[NH:41]C1CCNCC1)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[F:34][C:32]1[CH:31]=[C:30]2[C:26]([CH:27]=[CH:28][NH:29]2)=[C:25]([C:14]2[N:15]=[C:16]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:17]3[S:18][C:10]([CH2:9][N:4]4[CH2:3][CH2:2][CH:1]([NH2:41])[CH2:6][CH2:5]4)=[CH:11][C:12]=3[N:13]=2)[CH:33]=1

Participants

4

Reactant 3

HCID 7238334-(N-Boc-amino)piperidineHCID 21863450Trifluoroacetic acid methylene chlorideHCID 24936355HCID 24936355, compound

Product 1

HCID 59151279HCID 59151279, compound

Procedure

Prepared according to the method used in the preparation of 6-(cis-3,5-dimethyl-piperazin-1-ylmethyl)-2-(6-fluoro-1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, using piperidin-4-yl-carbamic acid tert-butyl ester in place of 2,6-dimethyl-piperazine, followed by BOC-deprotection using TFA:DCM (1:1). The title compound was obtained as a white solid (25 mg, 33%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-825fbd3205da4bfaa5e642c2f30f6fd4
Source dataset
uspto-grants-2012_08
Patent number
US08252792B2

Reaction notes

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