1-Pyrrolidineethanamine → HCID 136341002, compound

Participants

Reaction Steps

The intermediate 15 (120 mg, 0.5 mmol) and N-(2-amino-ethyl)pyrrolidine (59 mg, 0.5 mmol) was dissolved in DMF (4 mL). triethylamine (260 mg, 2.6 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (98 mg, 0.5 mmol) and 1-hydroxybenzotriazole monohydrate (39 mg, 0.3 mmol) were successively added to the resulting mixture at the room temperature. The obtained mixture was stirred at room temperature for 2 days. The solvent was removed under reduced pressure, and the resulting crude product was purified with a preparative HPLC system (the purification apparatus B) to afford crystalline product (15 mg, 9% yield).

Provenance & Evidence