Hydrochloric Acid → HCID 66989054, compound

Participants

Reaction Steps

A THF solution of lithium diisopropylamide prepared above was added in an ice bath dropwise to a THF (5 mL) solution of 1-(tert-butyl)-4-(di-tert-butyl)aminoindole (300 mg, 0.694 mmol) and triisopropyl borate (157 mg, 0.832 mmol) which was separately prepared. After the reaction solution was stirred in an ice bath for 1 hour, the solution was adjusted to pH3 with adding a 1M HCl solution. The resulting solution was extracted with ethyl acetate (15 mL×2), and the combined solution was dried over anhydrous magnesium sulfate to afford the crude product 53 of 1-(tert-butyl)-4-(ditert-butyl)amino-2-indoleboronic acid. The crude product was used for the next reaction without any further purification.

Provenance & Evidence