Phosphoric Acid → HCID 67434940, compound

Participants

Reaction Conditions

Reaction Steps

Combine 8-(2-Chloro-phenyl)-2-methyl-6-(4-methyl-piperazin-1-yl)-9-(tetrahydro pyran-4-yl)-9H-purine (3.0 g, 7.1 mmol) and absolute ethanol (24 mL) in a 50 mL 3-necked flask set up for reflux. Heat the resulting suspension to 70° C. and add 85% phosphoric acid (0.49 mL, 7.2 mmol) in absolute ethanol (6.0 mL) over 25 minutes. Stir the mixture at 70° C. for 45 minutes, cool slowly to ambient temperature and stir for an additional 2 hours. Filter the mixture, rinse the product cake with absolute ethanol (6 mL) and pull dry. Further dry the product overnight at 55° C. to afford the title compound as a white crystalline solid (3.6 g). MS (m/z): 427/429 (M+1).

Provenance & Evidence