Diisopropylethylamine → N-(5-tert-butyl-2-methylphenyl)-5-fluoro-2-[4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl]pyrimidin-4-amine

Participants

Reaction Steps

A solution of the product of Step 1 (123 mg, 0.42 mmol), 4-(1H-1,2,3-triazol-1-yl)piperidine (94 mg, 0.50 mmol) and diisopropylethylamine (2 mL) was irradiated in 2-propanol (2 mL), in a microwave oven, at 150° C. for 2 h. The mixture was cooled and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel Biotage 40S, eluting with EtOAc/hexane (0%-100%) to give the product (59 mg, 34%) as a solid.

Provenance & Evidence