Potassium Carbonate → HCID 57988797, compound

Participants

Reaction Steps

A mixture of 1,3-dimethyl-8-(1H-pyrazol-4-yl)-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (obtained following literature procedure U.S. Pat. No. 6,825,349) (0.100 g, 0.27 mmol), 1-(3-Bromo-prop-1-ynyl)-3-fluoro benzene (0.057 g, 0.27 mmol), K2CO3 (0.086 mg, 0.62 mmol) and acetone (5 ml) were refluxed at 80° C. for 5 hrs. The reaction mixture was cooled to room temperature and filtered off solid K2CO3 and evaporated excess of organic solvent under vacuum. The product was purified by column chromatography (2% methanol in dichloromethane) to get pure 8-{1-[3-(3-fluoro-phenyl)-prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dimethyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.111 g, 82%).

Provenance & Evidence