反应详情

温度

52.5 °C

4-Benzyloxy-benzoic acid methyl ester (8.0 g, 0.033 mol) was dissolved in THF:methanol:water (3:2:1, 80 ml) and NaOH (1.98 g, 0.05 mol) was added to the reaction mixture and stirred at 50-55° C. for 3 hours. Solvents were removed and residue was diluted with water, washed with hexane and acidified with dil HCl to obtain 4-benzyloxy-benzoic acid (7.0 g, 92%) as a white solid.

1. customSolvents were removed
2. additionresidue was diluted with water
3. washwashed with hexane