HCID 23588607, compound → HCID 135617740, compound

HRID 889009Notes

Reaction equation

HRID 889009 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:23]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:22]3[C:21](=[O:32])[N:20]([CH2:33][CH2:34][CH3:35])[C:19](=[O:36])[N:18]([CH2:37][CH2:38][CH3:39])[C:17]=3[N:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:23]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:31])[CH3:30])[C:22]3[C:21](=[O:32])[N:20]([CH2:33][CH2:34][CH3:35])[C:19](=[O:36])[N:18]([CH2:37][CH2:38][CH3:39])[C:17]=3[N:16]=2)=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 23588607HCID 23588607, compound

Product 1

HCID 135617740HCID 135617740, compoundYield 95.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 8-(4-benzyloxy-phenyl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.500 g, 0.91 mmol) in methanol (10 ml), 10% Pd/C (0.150 g) was added and stirred at room temperature under hydrogen atmosphere for 2 hours. The mixture was filtered, solvent was removed and the residue was washed with hexane to obtain 8-(4-hydroxy-phenyl)-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione as a white solid (0.398 g, 95%).

Workup

  1. filtrationThe mixture was filtered
  2. customsolvent was removed
  3. washthe residue was washed with hexane

Sources & evidence

ORD record
ord-2b4160531c784776b6a4fa2c1fca726a
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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