Dimethyl Sulfoxide → HCID 57988793, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,3-dipropyl-8-(1-prop-2-ynyl-1H-pyrazol-4-yl)-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.1 g, 0.212 mmol), N-methyl piperazine (0.025 g, 0.254 mmol), formaldehyde (0.08 ml), CuI (0.008 g), and DMSO (2 ml) was stirred at 30° C. for 72 hours. The mixture was cooled to 25° C. and the residue was diluted with water (10 ml) and extracted with ethylacetate (2×10 ml). The organic layer was washed with saturated brine solution (50 ml) and dried over Na2SO4. The solvent was evaporated to obtain pure 8-{1-[4-(4-Methyl-piperazin-1-yl)-but-2-ynyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.105 g, 85%).

Provenance & Evidence