Water → HCID 57988795, compound

Participants

Reaction Steps

To a solution of 3-(3-{4-[2,6-dioxo-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-pyrazol-1-yl}-prop-1-ynyl)-benzoic acid ethyl ester (50 mg, 0.08 mmol) in THF (5 ml), NaBH4 (5 mg, 0.16 mmol) was added slowly at 0° C. It was stirred for 3 h at room temperature. Water was added to reaction mixture and extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and then filtered and concentrated under vacuum. The residue obtained was purified by column chromatography to obtain 8-{1-[3-(3-hydroxymethyl-phenyl)-prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (25 mg, 54%) as an yellow oil.

Provenance & Evidence