Ethanol → HCID 57429663, compound

Participants

Reaction Steps

To a stirred solution of [5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-acetonitrile (0.25 g, 0.93 mmol) in ethanol (6 mL) was added sodium hydroxide solution (0.074 g, 1.86 mmol, in 3 ml water). The reaction mixture was refluxed for 3 hrs and the solvents were removed under reduced pressure, diluted with water (3 ml), washed with hexane (3×10 mL) and acidified with 2N HCl. The aqueous layer was extracted with DCM (3×15 mL) and the combined extract was washed with brine, dried with Na2SO4, evaporated under reduced pressure to obtain [5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-acetic acid (0.2 g, 77%) as an off white semi solid.

Provenance & Evidence