Methanesulfonyl chloride → HCID 57429671, compound

Participants

Reaction Steps

To a mixture of solution of [5-(4-Fluoro-benzyl)-4,5-dihydro-isoxazol-3-yl]-methanol (80 mg, 0.38 mmol), TEA (57 mg, 0.57 mmol) in DCM (10 ml), methanesulfonyl chloride (43 mg, 0.38 mmol) was added slowly at 0° C. and the mixture was stirred at room temperature for 3 hrs. Aqueous NaHCO3 was added to the reaction mixture and extracted with methylene dichloride. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated under vacuum. The residue obtained was purified by column chromatography to obtain Methanesulfonic acid 5-(4-fluoro-benzyl)-4,5-dihydro-isoxazol-3-ylmethyl ester (82 mg, 75%) as brown oil.

Provenance & Evidence