HCID 57988766, compound → HCID 57429648, compound

Participants

Reaction Steps

To a solution of 8-{1-[5-(4-Fluoro-benzyl)-4,5-dihydro-isoxazol-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (80 mg) in ethanol (5 ml) aq. HCl (2 N, 5 ml) was added and the reaction mixture was refluxed for 2 hrs. The volatiles were evaporated and the residue obtained was dissolved in ethyl acetate and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated under vacuum. The residue obtained was purified by column chromatography to obtain 8-{1-[5-(4-Fluoro-benzyl)-4,5-dihydro-isoxazol-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (100 mg, 98%) as white solid.

Provenance & Evidence