Thionyl Chloride → HCID 57429672, compound

HRID 889052Notes

Reaction equation

HRID 889052 reaction equation
[O:1]=[C:2]1[N:10]([CH2:11][CH2:12][CH3:13])[C:9]2[N:8]=[C:7]([C:14]3[CH:15]=[N:16][N:17]([CH2:19][C:20](O)=[O:21])[CH:18]=3)[N:6](COCC[Si](C)(C)C)[C:5]=2[C:4](=[O:31])[N:3]1[CH2:32][CH2:33][CH3:34].S(Cl)([Cl:37])=O>>[O:1]=[C:2]1[N:10]([CH2:11][CH2:12][CH3:13])[C:9]2[N:8]=[C:7]([C:14]3[CH:15]=[N:16][N:17]([CH2:19][C:20]([Cl:37])=[O:21])[CH:18]=3)[NH:6][C:5]=2[C:4](=[O:31])[N:3]1[CH2:32][CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 57988785HCID 57988785, compound

Product 1

HCID 57429672HCID 57429672, compound

Procedure

{4-[2,6-Dioxo-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-pyrazol-1-yl}-acetic acid (350 mg, 0.71 mmol) was taken with thionyl chloride (25 ml) and refluxed for 3 hrs. The volatiles were evaporated to obtain [4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-pyrazol-1-yl]-acetyl chloride (400 mg) as a yellow solid.

Workup

  1. temperaturerefluxed for 3 hrs
  2. customThe volatiles were evaporated

Sources & evidence

ORD record
ord-f9299137c9104de89bbb9bc7927da1b0
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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