HCID 57988791, compound → HCID 44236476, compound

HRID 889066Notes

Reaction equation

HRID 889066 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][N:14]1[C:22]2[N:21]=[C:20]([C:23]3[CH:24]=[N:25][N:26]([CH2:28][CH:29]4[CH2:33][C:32](=[O:34])[N:31]([C:35]5[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[CH:36]=5)[CH2:30]4)[CH:27]=3)[NH:19][C:18]=2[C:17](=[O:45])[N:16]([CH2:46][CH2:47][CH3:48])[C:15]1=[O:49]>CCO>[NH2:3][CH2:12][CH2:13][N:14]1[C:22]2[N:21]=[C:20]([C:23]3[CH:24]=[N:25][N:26]([CH2:28][CH:29]4[CH2:33][C:32](=[O:34])[N:31]([C:35]5[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[CH:36]=5)[CH2:30]4)[CH:27]=3)[NH:19][C:18]=2[C:17](=[O:45])[N:16]([CH2:46][CH2:47][CH3:48])[C:15]1=[O:49]

Participants

3

Reactant 1

HCID 57988791HCID 57988791, compound

Product 1

HCID 44236476HCID 44236476, compoundYield 44.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-8-{1-[5-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydro-purine-2,6-dione (56 mg, 0.083 mmol) was taken in EtOH (10 ml) to this monohydrated N2H4 (8.3 mg, 0.16 mmol) was added and stirred the reaction mixture for 1 h at room temperature. After completion of the reaction, solvent was evaporated under vacuum, solid was filtered, washed with DCM and the fitrate was concentrated to give the pure product (20 mg, 44%) as white solid.

Workup

  1. additionwas added
  2. customAfter completion of the reaction, solvent
  3. customwas evaporated under vacuum, solid
  4. filtrationwas filtered
  5. washwashed with DCM
  6. concentrationthe fitrate was concentrated

Sources & evidence

ORD record
ord-d03b8d41576e4fb18d429d4ca979ab5a
Source dataset
uspto-grants-2012_08
Patent number
US08252797B2

Reaction notes

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