HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-furanecarboxylic acid → HCID 59268848, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-furanecarboxylic acid | HCID 68511 | — |
| Reactant | Glutamic acid diethyl ester hydrochloride | HCID 73960 | — |
| Product | HCID 59268848 | HCID 59268848 | 72% |
Reaction Steps
AAG154489 was synthesized as shown in Scheme 3. Compounds 10 was obtained by a Sonogashira coupling of 5a (from scheme 1) with (S)-2-[(5-bromo-furan-2-carbonyl)-amino]-pentanedioic acid diethyl ester 13. Compound 13 (Scheme 3) was synthesized by coupling the commercially available 5-bromo-2-furan-carboxylic acid 12 and L-glutamate diethyl ester hydrochloride in 72% yield. Hydrogenation and saponification of 10 afforded AAG154489.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252804B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-acb51f3ccaf4410c8e1f76fe77063ed3 |
| Source note | uspto-grants-2012_08 |