Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2,4-Dichloroquinazoline | HCID 252886 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 22692581 | HCID 22692581 | 63.2% |
Reaction Steps
2,4-Dichloroquinazoline (500 mg, 2.5 mmol) was dissolved in acetonitrile (3 mL). Aniline (260 mg, 2.76 mmol) and triethylamine (380 mg, 3.75 mmol) were added. The mixture was shaken in a sealed vial on a sand bath at 60° C. for 12 hours. Filtration and evaporation of the filtrate gave a yellow solid. Column chromatography (ethylacetate:hexane) gave (2-chloro-quinazolin-4-yl)-propylamine (350 mg, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08252806B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-4c9a5229d7764fa7b5b2f32c72365788 |
|---|
| Source note | uspto-grants-2012_08 |
|---|
