4-Aminotetrahydropyran → 5-Methyl-4-(tetrahydropyran-4-yl)-2,4-dihydro[1,2,4]triazol-3-one

Participants

Reaction Conditions

Reaction Steps

After dissolving 5-methyl-3H-[1,3,4]oxadiazol-2-one (CAS 3069-67-8) (500 mg) in methanol (5 ml), 4-aminotetrahydropyran (1.01 g) was added and the mixture was heated to reflux for 15 hours. The reaction mixture was concentrated under reduced pressure, and then a 1N aqueous solution of sodium hydroxide (5.5 ml) was added to the residue and the mixture Was stirred at 100° C. for 2 hours. After then adding 5N hydrochloric acid (1.1 ml) to the reaction mixture, it was stirred at room temperature for 3 hours. The precipitate was collected by filtration and washed with water and ethyl acetate in that order to obtain the title compound (400 mg).

Provenance & Evidence