Ethyl chloroformate → HCID 68675322, compound

HRID 889161Notes

Reaction equation

HRID 889161 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[IH:7].[CH3:8][N:9]1[CH2:13][CH2:12][N:11]=[C:10]1[NH:14][NH2:15]>N1C=CC=CC=1>[IH:7].[CH2:5]([O:4][C:2]([NH:15][NH:14][C:10]1[N:9]([CH3:8])[CH2:13][CH2:12][N:11]=1)=[O:3])[CH3:6]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 2145886149541-82-4

Product 1

HCID 68675322HCID 68675322, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Ethyl chloroformate (0.95 ml) was added dropwise to a mixture of (1-methyl-4,5-dihydro-1H-imidazol-2-yl)-hydrazine hydroiodide (CAS 49541-82-4) (2 g) and pyridine (40 ml) while stirring, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off and the residue was purified by silica gel column chromatography. The obtained compound was washed with diethyl ether to obtain the title compound (1.14 g).

Workup

  1. stirringthe mixture was stirred at room temperature for 2 hours
  2. distillationThe solvent was distilled off
  3. customthe residue was purified by silica gel column chromatography
  4. washThe obtained compound was washed with diethyl ether

Sources & evidence

ORD record
ord-2e0b6e814d9f4028b7332515d872a272
Source dataset
uspto-grants-2012_08
Patent number
US08252810B2

Reaction notes

Loading…