3-Bromopropionaldehyde dimethylacetal → HCID 57927656, compound

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Reaction Steps

After suspending 3-methyl-5,6,7,8-tetrahydro-1H-quinazoline-2,4-dione (CAS 85458-77-1) (500 mg) in methanol (10 ml), potassium tert-butoxide (342 mg) was added and the mixture was stirred at room temperature for 30 minutes. After then adding 3-bromopropionaldehyde dimethylacetal (0.57 ml), the mixture was heated to reflux for 5 hours. The reaction mixture was concentrated under reduced pressure, water was added to the residue, and extraction was performed with ethyl acetate. The organic layer was washed with water and brine in that order and then dried over anhydrous magnesium sulfate. After filtration, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (235 mg).

Provenance & Evidence