HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 3-(4-acetamidopiperidin-1-yl)propanoate → 3-(4-Acetamidopiperidin-1-yl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 3-(4-acetamidopiperidin-1-yl)propanoate | HCID 66760069 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Acetamidopiperidin-1-yl)propanoic acid | HCID 66760367 | 93.3% |
Reaction Steps
A mixture of benzyl 3-(4-acetamidopiperidin-1-yl)propanoate (3.81 g, 12.5 mmol) and Pd/C (10%, 0.20 g) in methanol (100 mL) was stirred under hydrogen atmosphere overnight. The solid was filtered and the filtrate was evaporated to give 3-(4-acetamidopiperidin-1-yl)propanoic acid (2.50 g). LCMS (+ESI) 215 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08252793B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-81e61f3a18304cb2896bac7ffc8f53fd |
| Source note | uspto-grants-2012_08 |