3-(4-Acetyl-piperazin-1-yl)-propionic acid → HCID 66760558, compound

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2-amino-N-(2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)-N-methylacetamide and 3-(4-acetylpiperazin-1-yl)propanoic acid were used to prepare 16 as described for compound 1. LCMS (+ESI) 668 (M). 1H-NMR (CDCl3, δ): 8.58 (m, 1H), 7.84 (bt, 1H), 7.58 (t, J=2.0 Hz, 1H), 7.47 (d, J=8.8 Hz, 1H), 7.30 (d, J=8.8 Hz, 1H), 7.18 (m, 1H), 7.03 (t, J=8.0 Hz, 1H), 6.92 (d, J=8.0 Hz, 1H), 6.82 (m, 2 H), 5.68 (d, J=4.0 Hz, 2H), 5.28 (s, 2H), 4.21 (s, 3H), 3.89 (dd, 1H), 3.69 (m, 2H), 3.25 (s, 3H), 2.53 (m, 4H), 2.04 (s, 3H). Calcd. for C33H37Cl2N7O5+1H2O: C, 56.57; H, 5.61; N, 13.99. Found: C, 56.33; H, 5.48; N, 14.21.

Provenance & Evidence