反应详情

2-Amino-N-[2,4-dichloro-3-(2-ethyl-1-pyridin-2-ylmethyl-1H-benzoimidazol-4-yloxymethyl)-phenyl]-N-methyl-acetamide and 3-(4-(methylcarbamoyl)piperazin-1-yl)propanoic acid were coupled as described for compound 1 above to give 19. MS (APCI) 694 (M+), 1HNMR (400 MHz, MeOD) δ 2.12 (t, 3H), 2.49 (t, 2H), 2.71 (m, 4H), 2.89 (s, 3H), 2.89 (m, 2H), 2.93 (q, 2H), 3.2 (s, 3H), 3.31 (m, 4H), 3.46-3.84 (dd, 3H), 5.55 (m, 4H), 6.93-8.51 (m, 9Har), LCMS 695 (M+1); C34H38Cl2N8O4+1.73 H2O; Calculated: C, 56.69; H, 5.98; N, 15.56. Found: C, 56.69; H, 6.18; N, 15.81.