3-[4-[(Methanesulfonyl)amino]phenyl]propionic acid → N-(2-((2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-3-(4-(methylsulfonamido)phenyl)propanamide

Participants

Role	Name	HCID	Charge
Reactant	3-[4-[(Methanesulfonyl)amino]phenyl]propionic acid	HCID 13528372	—
Reactant	8-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-2-methyl-4-(2-pyridylmethoxy)quinoline	HCID 23292019	—
Reactant	4-(3-((2-((2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)amino)-3-oxopropyl)-N-(2-methoxyethyl)benzamide	HCID 66760978	—
Product	N-(2-((2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-3-(4-(methylsulfonamido)phenyl)propanamide	HCID 66760066	—

Reaction Steps

Compound 29 was prepared from 3-(4-(methylsulfonamido)phenyl)propanoic acid and 2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide in a as described for compound 1. MS (APCI) 736 (M+), 1H NMR (CDCl3) 2.45-2.56 (m, 2H), 2.65 (s, 3H), 2.83-2.92 (m, 5H), 3.15 (s, 3H), 3.35-3.48 (m, 1H), 3.75-3.85 (m, 1H), 5.41 (s, 2H), 5.61 (s, 2H), 6.61-6.65 (m, 1H), 6.71 (s, 1H), 7.15 (s, 4H), 7.24-7.34 (m, 2H), 7.3-7.45 (m, 5H), 7.56-7.61 (d, 1H, J=7.8 Hz), 7.66-7.78 (m, 1H), 7.91-7.94 (dd, 1H, J=1, 7.74 Hz), 8.64 (d, 1H, J=4.14 Hz).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08252793B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-9ba3cda13b0a488b8b5f3b0fd92fca0f
Source note	uspto-grants-2012_08