反应详情

(Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester (4.3 g, 20 mmol) and cyclopropylamine (1.14 g, 20 mmol) were stirred at room temperature in acetic acid (40 ml) for 2 hrs. The reaction mixture was diluted slowly with 30 ml of water and evaporated under vacuum at 35° C. Water (30 ml) was added to the residue and evaporated again at 35° C. The same procedure was repeated twice with toluene (30 ml each) to obtain the desired crude product as a dark brown oil [MS: m/e=227.4 (M+H+)], which could be used without any further purification for the next step.

1. customevaporated under vacuum at 35° C
2. additionWater (30 ml) was added to the residue
3. customevaporated again at 35° C
4. customto obtain the desired crude product as a dark brown oil [MS: m/e=227.4 (M+H+)], which
5. customcould be used without any further purification for the next step