Ethanol → 3-(6-(Methylcarbamoyl)pyridin-3-yl)propanoic acid
Reaction equation
C([O:8][C:9](=[O:22])[CH:10]=[CH:11][C:12]1[CH:13]=[N:14][C:15]([C:18](=[O:21])[NH:19][CH3:20])=N[CH:17]=1)C1C=CC=CC=1.[CH2:23](O)C>[Pd]>[CH3:20][NH:19][C:18]([C:15]1[CH:23]=[CH:17][C:12]([CH2:11][CH2:10][C:9]([OH:8])=[O:22])=[CH:13][N:14]=1)=[O:21]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-(2-methylcarbamoyl-pyrimidin 5-yl)acrylic acid benzyl ester in ethanol (20 mL) in presence of 15 mg of Pd/C, 10%, and stirred under hydrogen balloon overnight to give 3-(2-methylcarbamoyl-pyridine-5-yl)-propionic acid which was used without further purification.
Sources & evidence
- ORD record
- ord-4de765f456134da2ac9a0f3549efe584
- Source dataset
- uspto-grants-2012_08
- Patent number
- US08252793B2
Reaction notes
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