Benzyl 2-(2-(methylcarbamoyl)morpholino)acetate → HCID 66760446, compound

HRID 889216Notes

Reaction equation

HRID 889216 reaction equation
[CH3:1][NH:2][C:3]([CH:5]1[CH2:10][N:9]([CH2:11][C:12]([O:14]CC2C=CC=CC=2)=[O:13])[CH2:8][CH2:7][O:6]1)=[O:4]>C(O)C.[Pd]>[CH3:1][NH:2][C:3]([CH:5]1[CH2:10][N:9]([CH2:11][C:12]([OH:14])=[O:13])[CH2:8][CH2:7][O:6]1)=[O:4]

Participants

4

Reactant 1

HCID 66760795Benzyl 2-(2-(methylcarbamoyl)morpholino)acetate

Product 1

HCID 66760446HCID 66760446, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

benzyl 2-(2-(methylcarbamoyl)morpholino)acetate was dissolved in ethanol (40 mL), Pd/C 10% (100 mg) was added to the solution, and the mixture was stirred overnight under hydrogen (balloon) then filtered through celite and concentrated to give 2-(2-(methylcarbamoyl)morpholino)acetic acid. MS (APCI) 203 (M+1)

Workup

  1. filtrationthen filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d936177f550e403ab7f5393bfef6e89a
Source dataset
uspto-grants-2012_08
Patent number
US08252793B2

Reaction notes

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