HCID 59401842, compound → 2-methyl-4-(2-(R)-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Participants

Reaction Steps

A solution of 2-(2R)-methyl-1′-(3-methyl-4-nitro-phenyl)-[1,3′]bipyrrolidinyl (2 g, 6.9 mmol) in MeOH (15 mL) was de-aerated and nitrogen was introduced. To this solution was added Pd—C (10%, 0.20 g). The nitrogen was replaced with hydrogen and the mixture was stirred under H2 atmosphere at r.t. overnight. TLC (10% MeOH in DCM) and LC/MS showed the reaction was complete. The mixture was passed through a celite pad, rinsed with methanol. The filtrate was concentrated to dryness, and further dried under high vacuum to yield the title compound as a reddish brown liquid after drying under high vacuum, 2.02 g (100% yield).

Provenance & Evidence